Ion concentration assumptions break down in nanofluidic devices

Nanofluidic concentration devices for biomolecules utilizing ion concentration polarization: theory, fabrication, and applications.

Recently, a new type of electrokinetic concentration devices has been developed in a microfluidic chip format, which allows efficient trapping and concentration of biomolecules by utilizing ion concentration polarization near nanofluidic structures. These devices have drawn much attention not only due to their potential application in biomolecule sensing, but also due to the rich scientific con...

Enhanced Ion Current Rectification in 2D Graphene‐Based Nanofluidic Devices

Furthering the promise of graphene-based planar nanofluidic devices as flexible, robust, low cost, and facile large-scale alternatives to conventional nanochannels for ion transport, we show how the nonlinear current-voltage (I-V) characteristics and ion current rectification in these platforms can be enhanced by increasing the system asymmetry. Asymmetric cuts made to the 2D multilayered graph...

Finding a New Path when Assumptions Break Down

Restriction mapping in nanofluidic devices.

We have performed restriction mapping of DNA molecules using restriction endonucleases in nanochannels with diameters of 100-200 nm. The location of the restriction reaction within the device is controlled by electrophoresis and diffusion of Mg2+ and EDTA. We have successfully used the restriction enzymes SmaI, SacI, and PacI, and have been able to measure the positions of restriction sites wit...

Ion transport in nanofluidic channels.

In this tutorial review, recent developments in modeling and experimental studies on nanofludics were reported. Nanofluidic studies were categorized into two groups depending on the characteristic length scale. When the size of the nanochannels and pores is 5-100 nm, electrostatic interactions are dominant, and ion and fluid flow can be analyzed by continuum dynamics. Various nanofluidic device...